The semaglutide treatment dosing schedule is critical for its efficacy and safety. It specifies how frequently you should take the medicine, the scheduling of dosages, and any dose modifications required depending on individual response and tolerance.

IVitality recommends adherence to the suggested dose schedule. It is critical for attaining the best results while avoiding the risk of side effects.

How Many Times Do You Inject Semaglutide?

According to the semaglutide treatment dosing schedule, you can inject semaglutide once a week, regardless of meals. Use semaglutide injections on the same day of the week at any time. You can modify the day of the week you take semaglutide as long as it has been two days (48 hours) or more since your last dosage.

Categorized Semaglutide Treatment Dosing Schedule

We have categorized semaglutide dosage chart concerning the extent of its helpful impact on several health aspects, such as:

Type 2 Diabetes Mellitus (T2DM)

The dosage route is divided into:

Oral Administration

Take 3mg daily for 30 days as an initial dose. If additional glycemic control is desired after taking 7 mg for at least 30 days, dose may increase up to 14 milligrams daily orally once.

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Subcutaneous Administration

After four weeks on 0.25 mg subcutaneously once every week for four weeks, increase to 0.5 mg subcutaneously once weekly and adjust gradually over at least eight weeks to one mg once every eight weeks (Titration).

Maintenance Dose (0.5-1 mg subcutaneously once weekly, maximum 1 mg weekly).

Missed Doses for Type 2 Diabetes Mellitus

When missing a dosage, give it as soon as feasible within five days. Otherwise, omit the missed one and administer your next scheduled one on its usual date; resume once-week dosing after that.

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Cardiovascular Disease (CVD)

Semaglutide administration for CVD is described as:

Oral Tablets

For initial glycemic control, start taking 3 mg once daily by mouth for at least 30 days; after this point, increase to 7 mg. To achieve better control after taking 7 mg for at least 30 days, increase to 14 mg daily until the desired power is attained.

  • Maintenance Dose: 7-14 mg orally once a day
  • Maximum Dose: 14 milligrams per day

Subcutaneous Administration

The beginning dose should be 0.25 mg subcutaneously once weekly for four weeks, increasing to 0.5 mg once every week after that if additional control of diabetes remains required after at least four weeks on this dose; otherwise, increasing up to 1 mg once every week until other results occur.

  • Maintenance Dose: 0.5 to 1 mg subcutaneously once every week, up to 1 mg once weekly.
  • Maximum Dosage: 1 mg once every two weeks.

Semaglutide Treatment Dosing Schedule

Semaglutide 2.5mg/1ml = 7.5mg/3ml vial

Week Dose (mg) Units per 1ml Amount Used
1 0.25 10 10 units
2 0.25 10 10 units
3 0.25 10 10 units
4 0.25 10 10 units
5 0.5 20 20 units
6 0.5 20 20 units
7 0.5 20 20 units (1ml = 100 units)
8 0.5 20 20 units
9 1 40 40 units
10 1 40 40 units (2ml = 200 units)
11 1 40 40 units
12 1 40 40 units (3ml = 300 units)
13 Continue with the dosage plan from your provider

Weeks 13–16: 1.7 mg subcutaneously once per week.

  • Store medication in the refrigerator, but avoid freezing it.
  • Continue with your current dose if it’s effective for you.
  • Dose adjustment should be gradual, considering tolerability and weight loss.
  • Patients can continue their weight loss journey with slower titration schedules.
  • Drug tolerance and weight loss outcomes vary among individuals.
  • After eight weeks, increase the dose by ten units instead of doubling.
  • Decrease the dose gradually if symptoms or side effects arise.
  • Reduce dose by up to 50% until symptoms or side effects subside.
  • Increase fibre intake to alleviate constipation.
  • Consider using stool softeners like MiraLAX if needed.
  • Maintain an exercise and healthy eating routine.
  • Take prescribed vitamins and supplements.
  • Eat smaller, more frequent meals to prevent low blood sugar symptoms.

Maintenance Dosage

Week 17 and beyond: 2.4 mg subcutaneously once per week.

Missed Dose for Weight Loss

If a prescription has been missed and its subsequent planned dose falls over 48 hours from now, manage it when practical. On the other hand, you should not give it if the next scheduled dose is less than 72 hours away (less than 48 hours). Continue dosing on the typically scheduled day of the week.

If more than two consecutive doses are missed, continue dosing as scheduled or restart following the dosage escalation schedule, which may lessen the frequency of gastrointestinal problems associated with reinitiation of therapy.

Renal Dose Adjustments

No adjustment is recommended.


No modification is indicated for ESRD as no particular data is available for dialysis.

Liver Dose Adjustments

No adjustment is recommended.

Precautionary Measures for Patients

  • Regarding the liraglutide treatment dosing schedule, you (the patient) and your guardians must be aware of the following precautionary measures:
  • Patients should be encouraged to read the US FDA-approved patient labeling (Medication Guide and Instructions for Use).
  • We warn that patients undergoing subcutaneous treatment should not share a pen with another person, even if the needle has been replaced; patients should be aware that sharing needles or syringes with others increases the risk of blood-borne pathogen transmission.
  • Patients ought to be educated to report thyroid growth side effects like a lump in their neck, constant throat roughness, dysphagia, or dyspnea, as well as any irregularities in vision.
  • Patients ought to be educated concerning the chance of gastrointestinal (GI) unfriendly impacts and play it safe to limit dehydration; patients ought to be told to look for clinical consideration, assuming that they believe they are getting dehydrated or have tireless and extreme GI occasions.
  • Patients ought to be educated about the chance of pancreatitis and urged to end treatment immediately and contact their medical services expert if pancreatitis is thought of.
  • Ladies of childbearing age ought to see their medical care expert to become pregnant; there might be a threat to the baby.

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The Bottom Line

During times of stress, such as fever, trauma, infection, or surgery, semaglutide treatment dosing schedule for patients with diabetes must be under strict medical advice. It is because diabetes medical treatment may change. Therefore, you must know about the signs and side effects of the unusual medical issue so you can get it treated on time.